Programmable editing of primary MicroRNA switches stem cell differentiation and improves tissue regeneration

We developed a system called REPRESS to edit primary microRNA and inhibit microRNA expression. See more at Nature Communications.

Bi-directional gene activation and repression promote ASC differentiation and enhance bone healing in osteoporotic rats

We developed a system called CRISPR-BiD to turn on and off genes in adipose-derived stem cells from osteoporotic animal, switching the cells from adipogenic-prone to chondrogenic-like phenotypes for tissue engineering. See more at Molecular Therapy.

CRISPRai for simultaneous gene activation and inhibition to promote stem cell chondrogenesis and calvarial bone regeneration

We developed all-in-one CRISPRai system to turn on and off genes in bone marrow-derived stem cells, promoting chondrogenic differentiation and bone healing. See more at Nucleic Acids Research.